Parkinson's Disease, Animation

Parkinson disease: pathology, symptoms, causes and treatments (medications and surgery).
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Voice by: Ashley Fleming
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Parkinson's disease, or PD, is a neurodegenerative disorder in which DOPAMINE-producing neurons of a brain structure called the SUBSTANTIA NIGRA, are damaged and die over time, leading to a number of MOTOR problems and mental disabilities.
The substantia nigra is part of the basal ganglia, whose major function is to INHIBIT UNwanted motor activities. When a person intends to make a movement, this inhibition is removed by the action of dopamine. As dopaminergic neurons are progressively lost in PD patients, LOW levels of dopamine make it HARDER to INITIATE voluntary movements.
The events leading to neuronal cell death are poorly understood but the presence of so-called “Lewy bodies” in the neurons before they die may offer a clue and is currently the subject of intensive research.
Symptoms develop slowly over time; most prominent are MOTOR problems which include hand tremors, slow movements, limb rigidity and problems with gait and balance. These motor symptoms are collectively known as "PARKINSONISM". However, parkinsonism may also be caused by a variety of other factors, which must be excluded before a person can be diagnosed with PD. Other motor-related problems may include slurred speech and reduced facial expressions. In later stages, non-motor symptoms such as mood and behavioral changes, cognitive impairment and sleep disturbances… may be observed.
The cause of Parkinson's remains largely unknown but is likely to involve both genetic and environmental factors.
There is no cure for PD but current treatments are effective in managing motor symptoms:
First-line treatment involves medications which aim to INcrease dopamine levels in the brain. Major classes of medication include:
- Levodopa, a precursor of dopamine: levodopa can cross the blood brain barrier and is converted into dopamine inside the brain. Levodopa is the most effective of all medications but because it also produces dopamine elsewhere in the body, its side effects may become serious in the long-term. For this reason, levodopa is always administered together with some other drugs that inhibit its action OUTSIDE the brain.
- Dopamine agonists: substances that bind to dopamine receptors and mimic the action of dopamine.
- Another class of drugs includes INHIBITORS of enzymes that break down dopamine.
For people who do NOT respond to medications, surgery may be recommended. The most commonly performed procedure, deep brain stimulation, involves the implantation of a device called a neurostimulator, which sends electrical impulses to specific parts of the brain. By doing so, the device controls brain activities to relieve symptoms.

21 komento:

Alila Medical Media
Alila Medical Media:
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PCN Reiss
PCN Reiss:
Thank you.
This just made my reading like 100 times easier😚
Vanshika Singh
Vanshika Singh:
Thank you💜 This really helped me in my biology project.
Ahmed Farouk
Ahmed Farouk:
easy to understand with really excellent presentation
Rodney Evans
Rodney Evans:
Thank you!
Thank you. What a posotive video .
Wii U
Wii U:
Quick thought, why don’t nanobots (similar to that used in eye treatments) help encourage neurogenesis (the growth of new brain cells)? The technology has been used to treat colorblindness and other impairments by removing cells, or stimulating the growth of new cells by supplying certain chemicals needed for regeneration of cells. It would be easy for the nanobots to reach this portion of the brain, and they could leave the brain without much effort compared to implants, which are generally permanent. If genetics are an issue, crispr may also be an option as it can target, and replace, specific gene markers to that of a healthy person. This could really go a long way in the next 10 years if scientists put their minds to it.
Abal-Ashraf Affan
Abal-Ashraf Affan:
a wonderful video very short and precise..thank you
Today PD is 10 Marks in Our Final Year Exams. 🤪😅😷
wenzeslaus materu
wenzeslaus materu:
thank you 👍
Thank you ❤
Your videos are always great.I love your videos all time.
Leebron 8
Leebron 8:
nice explanation
deep waters
deep waters:
Maria Rafique
Maria Rafique:
Roman T
Roman T:
Hero Jabar
Hero Jabar:
thats a pacemaker not a stimulator
kinda cringe bro
Vikas Maluja
Vikas Maluja:
Nice video!!! No doubt it’s an chronic disorder but you can take Planet Ayurveda's pakeinons pack and you don’t have to eat medicines throughout life.
abdur rehman
abdur rehman:
Fasting is a cure for Parkinson disease according to Professor Mark Mattson of Hopkins University